Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;96(1):47-53.
doi: 10.1111/cen.14620. Epub 2021 Oct 25.

Copeptin assays in children for the differential diagnosis of polyuria-polydipsia syndrome and reference levels in hospitalized children

Laura Bonnet  1 , Emeline Marquant  1 , Julien Fromonot  1 , Ilyes Hamouda  1 , Julie Berbis  1 , Alice Godefroy  1 , Melody Vierge  1 , Michel Tsimaratos  1 , Rachel Reynaud  1
Affiliations

Copeptin assays in children for the differential diagnosis of polyuria-polydipsia syndrome and reference levels in hospitalized children

Laura Bonnet et al. Clin Endocrinol (Oxf). 2022 Jan.

Abstract

Objectives: Polyuria-polydipsia syndrome (PPS) is a common presentation in children but the differential diagnosis rests on burdensome water deprivation tests. The aims of this study were to determine a copeptin threshold to distinguish patients with central diabetes insipidus from those with primary polydipsia and to estimate the normal range of copeptin concentrations in children.

Design: Single-centre retrospective descriptive study.

Patients: Two hundred and seventy-eight children aged 2 months to 18 years who consulted for PPS (N = 40) or other reasons (control group, N = 238) at La Timone University Hospital in Marseille, France, between April 2015 and September 2019 and had a copeptin assay.

Measurements: Ultrasensitive copeptin assays on blood samples.

Results: Among the children with PPS, the mean copeptin concentrations were 1.72, 55.2 and 15.7 pmol/l in those with central diabetes insipidus (N = 21), nephrogenic diabetes insipidus (N = 3), and primary polydipsia (N = 16), respectively. Copeptin levels lower than 3.53 pmol/l were diagnostic of central diabetes insipidus with 100% sensitivity and 87.4% specificity (p < .001). The 5th-95th copeptin percentile range in the control group was 2.53-21.03 pmol/L. Copeptin levels were significantly higher in boys than in girls but there was no association with age, pubertal stage, body mass index, or the reason for consulting.

Conclusions: Our results indicate copeptin assays may be valuable in the differential diagnosis of PPS in children. Larger prospective studies are required to establish their accuracy in everyday clinical practice.

Keywords: child; copeptin; diabetes insipidus; paediatric; polydipsia; polyuria; reference values.

PubMed Disclaimer

References

REFERENCES

    1. Piffaretti C, Mandereau-Bruno L, Guilmin-Crepon S, Choleau C, Coutant R, Fosse-Edorh S. Trends in childhood type 1 diabetes incidence in France, 2010-2015. Diabetes Res Clin Pract. 2019;149:200-207. doi:10.1016/j.diabres.2018.11.005
    1. Fenske WK, Schnyder I, Koch G, et al. Release and decay kinetics of copeptin vs AVP in response to osmotic alterations in healthy volunteers. J Clin Endocrinol Metab. 2018;103(2):505-513. doi:10.1210/jc.2017-01891
    1. Wun T. Vasopressin and platelets: a concise review. Platelets. 1997;8(1):15-22. doi:10.1080/09537109777492
    1. Kluge M, Riedl S, Erhart-Hofmann B, Hartmann J, Waldhauser F. Improved extraction procedure and RIA for determination of arginine8-vasopressin in plasma: role of premeasurement sample treatment and reference values in children. Clin Chem. 1999;45(1):98-103.
    1. Balanescu S, Kopp P, Gaskill MB, Morgenthaler NG, Schindler C, Rutishauser J. Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar states. J Clin Endocrinol Metab. 2011;96(4):1046-1052. doi:10.1210/jc.2010-2499

Publication types