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. 2022 Jan;37(1):200-205.
doi: 10.1002/mds.28826. Epub 2021 Oct 25.

Plasma Glutathione and Prodromal Parkinson's Disease Probability

Sokratis Charisis  1   2 , Eva Ntanasi  1   3 , Maria Stamelou  4   5 , Georgia Xiromerisiou  6 , Maria Maraki  7   8 , Aristidis S Veskoukis  9 , Mary Yannakoulia  3 , Mary H Kosmidis  10 , Costas A Anastasiou  3 , Nikolaos Giagkou  1   4 , Efthimios Dardiotis  6 , Georgios Hadjigeorgiou  11 , Paraskevi Sakka  12 , Demetrios Kouretas  13 , Leonidas Stefanis  1   14 , Nikolaos Scarmeas  1   15
Affiliations

Plasma Glutathione and Prodromal Parkinson's Disease Probability

Sokratis Charisis et al. Mov Disord. 2022 Jan.

Abstract

Background: A decrease in glutathione (GSH) levels is considered one of the earliest biochemical changes in Parkinson's disease (PD).

Objective: The authors explored the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD (pPD) by examining its longitudinal associations with pPD probability trajectories.

Methods: A total of 405 community-dwelling participants (median age [interquartile range] = 73.2 [7.41] years) without clinical features of parkinsonism were followed for a mean (standard deviation) of 3.0 (0.9) years.

Results: A 1 μmol/L increase in plasma GSH was associated with 0.4% (95% confidence interval [CI], 0.1%-0.7%; P = 0.017) less increase in pPD probability for 1 year of follow-up. Compared with participants in the lowest GSH tertile, participants in the highest GSH tertile had a 12.9% (95% CI, 22.4%-2.2%; P = 0.020) slower rate of increase of pPD probability for 1 year of follow-up.

Conclusion: Plasma GSH was associated with pPD probability trajectories; therefore, it might assist in the identification of individuals who are likely to reach the threshold for pPD diagnosis more rapidly. © 2021 International Parkinson and Movement Disorder Society.

Keywords: Parkinson's disease; oxidative stress; plasma glutathione; prodromal Parkinson's disease; redox biomarkers.

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References

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