Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study

Matthias M Mauschitz¹, Marie-Therese Schmitz², Timo Verzijden³, Matthias Schmid², Eric F Thee³, Johanna M Colijn³, Cécile Delcourt⁴, Audrey Cougnard-Grégoire⁴, Bénédicte M J Merle⁴, Jean-François Korobelnik⁴, Bamini Gopinath⁵, Paul Mitchell⁶, Hisham Elbaz⁷, Alexander K Schuster⁸, Philipp S Wild⁹, Caroline Brandl¹⁰, Klaus J Stark¹¹, Iris M Heid¹¹, Felix Günther¹², Annette Peters¹³, Caroline C W Klaver¹⁴, Robert P Finger¹⁵; European Eye Epidemiology (E3) Consortium

Affiliations

¹ Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany. Electronic address: Matthias.Mauschitz@ukbonn.de.
² Department of Medical Biometry, Informatics and Epidemiology (M.-T.S., M.S.), Medical Faculty, University of Bonn, Bonn, Germany.
³ Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands.
⁴ Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
⁵ Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia; Department of Linguistics (B.G.,), Macquarie University Hearing, Macquarie University, Sydney, New South Wales, Australia.
⁶ Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
⁷ Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Department of Ophthalmology (H.E.), Otto-von-Guericke University, Magdeburg, Germany.
⁸ Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
⁹ Preventive Cardiology and Preventive Medicine, Center for Cardiology (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; DZHK (German Center for Cardiovascular Research) (P.S.W.), partner site Rhine-Main, Mainz, Germany.
¹⁰ Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Department of Ophthalmology (C.B.), University Hospital Regensburg, Regensburg, Germany.
¹¹ Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany.
¹² Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Statistical Consulting Unit StaBLab, Department of Statistics (F.G.), Ludwig-Maximilians-University Munich, Germany.
¹³ Institute of Epidemiology (A.P.), Helmholtz Center Munich, Germany; Department of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology (A.P.), Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
¹⁴ Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Opthalmology (C.C.W.K.), Radboudumc, Nijmegen, the Netherlands; Institute of Molecular and Clinical Ophthalmology (C.C.W.K.), Basel, Switzerland.
¹⁵ Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany.

PMID: 34695401
DOI: 10.1016/j.ajo.2021.10.008

Meta-Analysis

Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study

Matthias M Mauschitz et al. Am J Ophthalmol. 2022 Apr.

. 2022 Apr:236:99-106.

doi: 10.1016/j.ajo.2021.10.008. Epub 2021 Oct 22.

Authors

Affiliations

¹ Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany. Electronic address: Matthias.Mauschitz@ukbonn.de.
² Department of Medical Biometry, Informatics and Epidemiology (M.-T.S., M.S.), Medical Faculty, University of Bonn, Bonn, Germany.
³ Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands.
⁴ Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
⁵ Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia; Department of Linguistics (B.G.,), Macquarie University Hearing, Macquarie University, Sydney, New South Wales, Australia.
⁶ Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
⁷ Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Department of Ophthalmology (H.E.), Otto-von-Guericke University, Magdeburg, Germany.
⁸ Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
⁹ Preventive Cardiology and Preventive Medicine, Center for Cardiology (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; DZHK (German Center for Cardiovascular Research) (P.S.W.), partner site Rhine-Main, Mainz, Germany.
¹⁰ Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Department of Ophthalmology (C.B.), University Hospital Regensburg, Regensburg, Germany.
¹¹ Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany.
¹² Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Statistical Consulting Unit StaBLab, Department of Statistics (F.G.), Ludwig-Maximilians-University Munich, Germany.
¹³ Institute of Epidemiology (A.P.), Helmholtz Center Munich, Germany; Department of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology (A.P.), Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
¹⁴ Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Opthalmology (C.C.W.K.), Radboudumc, Nijmegen, the Netherlands; Institute of Molecular and Clinical Ophthalmology (C.C.W.K.), Basel, Switzerland.
¹⁵ Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany.

PMID: 34695401
DOI: 10.1016/j.ajo.2021.10.008

Abstract

Purpose: To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population.

Design: Meta-analysis of longitudinal cohort studies.

Methods: We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD.

Results: At baseline, mean age was 60.7 ± 6.9 to 76.4 ± 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD.

Conclusions: Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact.

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Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study

Affiliations

Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study

Authors

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Abstract

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LinkOut - more resources

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Medical