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. 2021 Oct 8;9(10):1145.
doi: 10.3390/vaccines9101145.

Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination

Dong-Ho Jo  1 , Dohsik Minn  2 , Jaegyun Lim  3 , Ki-Deok Lee  1 , Yu-Min Kang  1 , Kang-Won Choe  1 , Kwang-Nam Kim  4
Affiliations

Rapidly Declining SARS-CoV-2 Antibody Titers within 4 Months after BNT162b2 Vaccination

Dong-Ho Jo et al. Vaccines (Basel). .

Abstract

The efficacy and safety of the BNT162b2 vaccine are known, but antibodies are expected to decrease over time after vaccination. We collected blood samples from 104 fully vaccinated health care workers at 3 and 5 weeks after first vaccination and 4 months after second vaccination. Antibody titers and neutralizing antibodies were measured. In our study, both antibody titers and neutralizing antibodies increased significantly at 5 weeks after first vaccination but decreased rapidly at 4 months after second vaccination. Additionally, the results showed a significant decrease regardless of gender or age. Further studies are needed to help determine the interval of SARS-CoV-2 vaccinations.

Keywords: BNT162 vaccine; SARS-CoV-2; antibodies; neutralizing antibodies; vaccine immunogenicity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) The total anti-S antibodies (including IgG) to the SARS-CoV-2 spike protein receptor binding domain (RBD) counts. Data were measured at 3 and 5 weeks after first vaccination and 4 months after second vaccination. (b) Neutralizing antibodies counts. Data were measured at 3 and 5 weeks after first vaccination, and 4 months after second vaccination with an ELISA-based SARS-CoV-2 Surrogate Virus Neutralization Test Kit.
Figure 2
Figure 2
(a) The total anti-S antibodies (including IgG) to the SARS-CoV-2 spike protein receptor-binding domain (RBD) counts by gender. Data were measured at 3 and 5 weeks after first vaccination and 4 months after second vaccination. (b) Neutralizing antibodies counts by gender. Data were measured at 3 and 5 weeks after first vaccination, and 4 months after second vaccination with an ELISA-based SARS-CoV-2 Surrogate Virus Neutralization Test Kit.
Figure 3
Figure 3
(a) The total anti-S antibodies (including IgG) to the SARS-CoV-2 spike protein receptor-binding domain (RBD) counts by age. Data were measured at 3 and 5 weeks after first vaccination and 4 months after second vaccination. (b) NeuTable 3 and 5 weeks after first vaccination and 4 months after second vaccination with an ELISA-based SARS-CoV-2 Surrogate Virus Neutralization Test Kit.
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