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Review
. 2022 Feb;32(2):124-139.
doi: 10.1016/j.tcb.2021.09.010. Epub 2021 Oct 22.

Emerging roles of peroxisomes in viral infections

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Review

Emerging roles of peroxisomes in viral infections

Ana Rita Ferreira et al. Trends Cell Biol. 2022 Feb.

Abstract

Peroxisomes, essential subcellular organelles that fulfill important functions in lipid and reactive oxygen species metabolism, have recently emerged as key players during viral infections. Their importance for the establishment of the cellular antiviral response has been highlighted by numerous reports of specific evasion of peroxisome-dependent signaling by different viruses. Recent data demonstrate that peroxisomes also assume important proviral functions. Here, we review and discuss the recent advances in the study of the diverse roles of peroxisomes during viral infections, from animal to plant viruses, and from basic to translational perspectives. We further discuss the future development of this emerging area and propose that peroxisome-related mechanisms represent a promising target for the development of novel antiviral strategies.

Keywords: cellular antiviral immunity; cellular metabolism; peroxisomes; viral infections; virus–host interactions.

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Conflict of interest statement

Declaration of interests J.C.K. holds equity in and consults for IFM Therapeutics and Corner Therapeutics; none of these relationships influenced the work performed in this study. The other authors declare no competing interests.

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