MSI-H/dMMR mCRC: ICIs in the first line?

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Comment

Peter Sidaway. Nat Rev Clin Oncol. 2021 Dec.

. 2021 Dec;18(12):748.

doi: 10.1038/s41571-021-00576-z.

No abstract available

Comment on

First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study.
Lenz HJ, Van Cutsem E, Luisa Limon M, Wong KYM, Hendlisz A, Aglietta M, García-Alfonso P, Neyns B, Luppi G, Cardin DB, Dragovich T, Shah U, Abdullaev S, Gricar J, Ledeine JM, Overman MJ, Lonardi S. Lenz HJ, et al. J Clin Oncol. 2022 Jan 10;40(2):161-170. doi: 10.1200/JCO.21.01015. Epub 2021 Oct 12. J Clin Oncol. 2022. PMID: 34637336 Clinical Trial.

1. Lenz, H. J. et al. First-line nivolumab plus low-dose ipilimumab for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: the phase II CheckMate 142 study. J. Clin. Oncol. https://doi.org/10.1200/JCO.21.01015 (2020) - DOI - PubMed