A vast potential genome editor toolbox

Affiliations

Comment

Grant Otto. Nat Rev Genet. 2021 Dec.

. 2021 Dec;22(12):747.

doi: 10.1038/s41576-021-00429-6.

No abstract available

Comment on

The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases.
Altae-Tran H, Kannan S, Demircioglu FE, Oshiro R, Nety SP, McKay LJ, Dlakić M, Inskeep WP, Makarova KS, Macrae RK, Koonin EV, Zhang F. Altae-Tran H, et al. Science. 2021 Oct;374(6563):57-65. doi: 10.1126/science.abj6856. Epub 2021 Sep 9. Science. 2021. PMID: 34591643 Free PMC article.
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas Č, Siksnys V. Karvelis T, et al. Nature. 2021 Nov;599(7886):692-696. doi: 10.1038/s41586-021-04058-1. Epub 2021 Oct 7. Nature. 2021. PMID: 34619744 Free PMC article.

1. Altae-Tran, H. et al. The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases. Science 374, 57–65 (2021) - DOI
1. Karvelis, T. et al. Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Nature https://doi.org/10.1038/s41586-021-04058-1 (2021) - DOI - PubMed