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. 2022:272:39-52.
doi: 10.1007/164_2021_556.

Antiproliferatives and Transplantation

Robert Donovan  1 , Howard Eisen  1 , Omaima Ali  2
Affiliations

Antiproliferatives and Transplantation

Robert Donovan et al. Handb Exp Pharmacol. 2022.

Abstract

Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially identified for use in autoimmune and cancer research due to their role in disruption of cellular replication. They have now become the cornerstone of antirejection maintenance therapy in solid organ transplant. In this chapter we will describe the major times that lead to discovery, mechanisms of action, side effects, use during pregnancy and the major clinical trials.

Keywords: Antiproliferatives; Azathioprine; Clinical trials; Discovery; Mechanism of action; Mycophenolic acid; Side effects.

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