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. 2022:272:39-52.
doi: 10.1007/164_2021_556.

Antiproliferatives and Transplantation

Robert Donovan  1 , Howard Eisen  1 , Omaima Ali  2
Affiliations

Antiproliferatives and Transplantation

Robert Donovan et al. Handb Exp Pharmacol. 2022.

Abstract

Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially identified for use in autoimmune and cancer research due to their role in disruption of cellular replication. They have now become the cornerstone of antirejection maintenance therapy in solid organ transplant. In this chapter we will describe the major times that lead to discovery, mechanisms of action, side effects, use during pregnancy and the major clinical trials.

Keywords: Antiproliferatives; Azathioprine; Clinical trials; Discovery; Mechanism of action; Mycophenolic acid; Side effects.

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References

    1. A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group (1996) Transplantation 61(7):1029–1037
    1. Aarbakke J, Janka-Schaub G, Elion GB (1997) Thiopurine biology and pharmacology. Trends Pharmacol Sci 18(1):3–7 - DOI
    1. Andreassen AK, Andersson B, Gustafsson F, Eiskjaer H, Rådegran G, Gude E et al (2016) Everolimus initiation with early calcineurin inhibitor withdrawal in de novo heart transplant recipients: three-year results from the randomized SCHEDULE study. Am J Transplant 16(4):1238–1247. https://doi.org/10.1111/ajt.13588 - DOI - PubMed
    1. Baran DA, Zucker MJ, Arroyo LH, Camacho M, Goldschmidt ME, Nicholls SJ et al (2011) A prospective, randomized trial of single-drug versus dual-drug immunosuppression in heart transplantation: the tacrolimus in combination, tacrolimus alone compared (TICTAC) trial. Circ Heart Fail 4(2):129–137. https://doi.org/10.1161/CIRCHEARTFAILURE.110.958520 - DOI - PubMed
    1. Bechstein WO, Suzuki Y, Kawamura T, Jaffee B, Allison A, Hullett DA et al (1992) Low-dose combination therapy of DUP-785 and RS-61443 prolongs cardiac allograft survival in rats. Transpl Int 5(Suppl 1):S482–S483 - DOI

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