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. 2022 Feb;196(4):963-968.
doi: 10.1111/bjh.17906. Epub 2021 Oct 25.

Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

Zaid H Abdel Rahman  1 , Ricardo D Parrondo  1 , Michael G Heckman  2 , Mikolaj Wieczorek  2 , Kevin C Miller  3 , Hassan Alkhateeb  4 , Lisa Z Sproat  5 , Hemant Murthy  1 , William J Hogan  4 , Mohamed A Kharfan-Dabaja  1 , Jess F Peterson  6 , Linda B Baughn  6 , Nicole Hoppman  6 , Mark R Litzow  4 , Rhett P Ketterling  6 , Patricia T Greipp  6 , James M Foran  1
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Comparative study of therapy-related and de novo adult b-cell acute lymphoblastic leukaemia

Zaid H Abdel Rahman et al. Br J Haematol. 2022 Feb.

Abstract

We report a comparative analysis of patients with therapy-related acute lymphoblastic leukaemia (tr-ALL) vs de novo ALL. We identified 331 patients with B-ALL; 69 (21%) were classified as tr-ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr-ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr-ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease-positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo-haematopoietic cell transplantation.

Keywords: ALL; FISH; leukemia; therapy-related.

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Conflict of interest statement

The authors have no relevant conflicts of interest.

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