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Review
. 2021 Nov;22(6):e74.
doi: 10.4142/jvs.2021.22.e74. Epub 2021 Aug 26.

Comparative characteristic study from bone marrow-derived mesenchymal stem cells

Medania Purwaningrum  1   2 , Nabila Syarifah Jamilah  1 , Steven Dwi Purbantoro  1 , Chenphop Sawangmake  1   3   4 , Sirirat Nantavisai  1   5
Affiliations
Review

Comparative characteristic study from bone marrow-derived mesenchymal stem cells

Medania Purwaningrum et al. J Vet Sci. 2021 Nov.

Abstract

Tissue engineering has been extensively investigated and proffered to be a potential platform for novel tissue regeneration. The utilization of mesenchymal stem cells (MSCs) from various sources has been widely explored and compared. In this regard, MSCs derived from bone marrow have been proposed and described as a promising cell resource due to their high yield of isolated cells with colony-forming potential, self-renewal capacity, MSC surface marker expression, and multi-lineage differentiation capacities in vitro. However, there is evidence for bone marrow MSCs (BM-MSCs) both in vitro and in vivo from different species presenting identical and distinct potential stemness characteristics. In this review, the fundamental knowledge of the growth kinetics and stemness properties of BM-MSCs in different animal species and humans are compared and summarized. Finally, to provide a full perspective, this review will procure results of current information studies focusing on the use of BM-MSCs in clinical practice.

Keywords: Tissue engineering; bone marrow mesenchymal stem cells; mesenchymal stem cells; stemness characteristics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1. Comparative morphology of BM-MSCs. Morphology (representative figures) of murine (A), canine (B), feline (C), and human (D) BM-MSCs are illustrated.
BM-MSCs, bone marrow mesenchymal stem cells.
Fig. 2
Fig. 2. Conceptualization of translational research to clinical application. Comparative MSCs characteristics from difference sources of bone marrow-MSCs in vitro used to translate research results into human and animal clinical applications is shown in the diagram.
MSCs, mesenchymal stem cells.
See this image and copyright information in PMC

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