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Review
. 2021 Oct 26;37(12):205.
doi: 10.1007/s11274-021-03173-5.

Recent progress on n-butanol production by lactic acid bacteria

Qi Li  1   2 , Jieze Zhang  3 , Junjie Yang  2 , Yu Jiang  4   5 , Sheng Yang  6   7
Affiliations
Review

Recent progress on n-butanol production by lactic acid bacteria

Qi Li et al. World J Microbiol Biotechnol. .

Abstract

n-Butanol is an essential chemical intermediate produced through microbial fermentation. However, its toxicity to microbial cells has limited its production to a great extent. The anaerobe lactic acid bacteria (LAB) are the most resistant to n-butanol, so it should be the first choice for improving n-butanol production. The present article aims to review the following aspects of n-butanol production by LAB: (1) the tolerance of LAB to n-butanol, including its tolerance level and potential tolerance mechanisms; (2) genome editing tools in the n-butanol-resistant LAB; (3) methods of LAB modification for n-butanol production and the production levels after modification. This review will provide a theoretical basis for further research on n-butanol production by LAB.

Keywords: Anaerobic; Butanol; Genome editing; Lactic acid bacteria; Metabolic engineering; Tolerance.

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