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Review
. 2022 Jan;49(1):735-746.
doi: 10.1007/s11033-021-06869-x. Epub 2021 Oct 26.

Role of formin INF2 in human diseases

Yiting Zhao  1   2 , Hui Zhang  3   2 , Haibiao Wang  4   5 , Meng Ye  6   7 , Xiaofeng Jin  8   9
Affiliations
Review

Role of formin INF2 in human diseases

Yiting Zhao et al. Mol Biol Rep. 2022 Jan.

Abstract

Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal segmental glomerulosclerosis and cancers, such as colorectal and thyroid cancer where it functions as a tumor suppressor, glioblastoma, breast, prostate, and gastric cancer, via its oncogenic function. However, studies on the underlying molecular mechanisms of the different roles of INF2 in diverse cancers are limited. This review comprehensively describes the structure, biochemical features, and primary pathogenic mutations of INF2.

Keywords: CMT; Cancers; FSGS; Formin; INF2; Mutations.

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References

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