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Case Reports
. 2022 Mar;49(3):299-305.
doi: 10.1111/cup.14156. Epub 2021 Nov 7.

Patch/plaque mycosis-fungoides-like presentations of DUSP22-translocated T-cell lymphomas

John S Runge  1 , Madison L Novice  1 , Naomi Briones  2 , Kiyanna Williams  2 , Lori Lowe  2   3 , Daniel F Boyer  3 , Ryan A Wilcox  4 , Trilokraj Tejasvi  2 , Alexandra C Hristov  2   3
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Free article
Case Reports

Patch/plaque mycosis-fungoides-like presentations of DUSP22-translocated T-cell lymphomas

John S Runge et al. J Cutan Pathol. 2022 Mar.
Free article

Abstract

The DUSP22-IRF4 gene rearrangement results in downregulation of DUSP22, a presumed tumor suppressor in T-cell lymphomagenesis. It has been described in some cases of primary cutaneous and systemic anaplastic large-cell lymphoma, lymphomatoid papulosis, and transformed mycosis fungoides. Here we describe two patients with clinical lesions resembling patch/plaque mycosis fungoides that did not meet WHO criteria for large-cell transformation on histopathology yet showed a DUSP22 translocation. One patient who had a history of systemic anaplastic large-cell lymphoma with DUSP22 translocation presented with cutaneous involvement by his systemic lymphoma along with lymphomatoid papulosis and mycosis-fungoides-like lesions, all showing an identical immunophenotype and T-cell clone. These cases expand the spectrum of DUSP22-rearranged lymphomas to include mycosis-fungoides-like presentations without large-cell transformation.

Keywords: CD30; DUSP22; T-cell lymphoma; anaplastic large-cell lymphoma; mycosis fungoides.

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References

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