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Comment
. 2022 Jan 1;106(1):e103-e104.
doi: 10.1097/TP.0000000000003966.

Poor Serologic Response to 2 Doses of an mRNA-based SARS-CoV-2 Vaccine in Lung Transplant Recipients

Thijs W Hoffman  1 , B Meek  2 , G T Rijkers  3 , D A van Kessel  1   4
Affiliations
Comment

Poor Serologic Response to 2 Doses of an mRNA-based SARS-CoV-2 Vaccine in Lung Transplant Recipients

Thijs W Hoffman et al. Transplantation. .
No abstract available

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Conflict of interest statement

The authors declare no funding or conflicts of interest.

Figures

FIGURE 1.
FIGURE 1.
Grouped scatter plot showing anti-SARS-CoV-2 IgG antibodies in lung transplant recipients before vaccination with SARS-CoV-2 vaccine, 4 wk after the first vaccination and 6 wk after the second vaccination. Error bars represent the group median with 25th and 75th percentiles. All values below the lower detection limit of the assay were set to 0. After the second vaccination, antibody levels were significantly higher in patients who had had COVID-19 before vaccination (n = 12) compared with patients who had not had COVID-19 (n = 80; median 800 AU/mL [IQR, 63.25–800] vs 0.00 [0.00–16.30]; P < 0.001). The dashed line represents the 2.5th percentile value of anti-SARS-CoV-2 IgG antibodies after the first and second vaccination in 102 healthy volunteers, as provided by the manufacturer (after the first vaccination, the 2.5th percentile was 25 AU/mL, and the median value 138 AU/mL; after the second vaccination, the 2.5th percentile was 372 AU/mL and the median value 1706 AU/mL) (https://www.diasorin.com/sites/default/files/immagini/ese_infografica_vaccinated_indivuduals_m0870004414_lr.pdf). COVID-19, coronavirus disease 2019; IgG, immunoglobulin G; IQR, interquartile range; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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References

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