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Comment
. 2021 Oct 25;56(20):2783-2784.
doi: 10.1016/j.devcel.2021.10.003.

Working together: Heterotypic clusters and collective cell migration in melanoma metastasis

William T Frantz  1 , Craig J Ceol  2
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Working together: Heterotypic clusters and collective cell migration in melanoma metastasis

William T Frantz et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Campbell et al. (2021) show that melanoma cells with distinct invasive or proliferative gene signatures can form heterotypic clusters that extravasate collectively and readily seed the growth of metastatic lesions. These findings highlight interactions between heterogenous tumor cells as being critical for metastasis.

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  • Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation.
    Campbell NR, Rao A, Hunter MV, Sznurkowska MK, Briker L, Zhang M, Baron M, Heilmann S, Deforet M, Kenny C, Ferretti LP, Huang TH, Perlee S, Garg M, Nsengimana J, Saini M, Montal E, Tagore M, Newton-Bishop J, Middleton MR, Corrie P, Adams DJ, Rabbie R, Aceto N, Levesque MP, Cornell RA, Yanai I, Xavier JB, White RM. Campbell NR, et al. Dev Cell. 2021 Oct 25;56(20):2808-2825.e10. doi: 10.1016/j.devcel.2021.08.018. Epub 2021 Sep 15. Dev Cell. 2021. PMID: 34529939 Free PMC article.

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