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. 2021 Oct 26;14(1):253.
doi: 10.1186/s12920-021-01100-z.

Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse

Vanessa Troiani  1   2   3   4 , Richard C Crist  5 , Glenn A Doyle  5 , Thomas N Ferraro  5   6 , Donielle Beiler  7 , Stephanie Ranck  7 , Kortney McBryan  7 , Margaret A Jarvis  7 , Jordan S Barbour  7 , John J Han  8 , Ryan J Ness  8 , Wade H Berrettini  7   6 , Janet D Robishaw  9
Affiliations

Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse

Vanessa Troiani et al. BMC Med Genomics. .

Abstract

Background: Prescription opioids (POs) are commonly used to treat moderate to severe chronic pain in the health system setting. Although they improve quality of life for many patients, more work is needed to identify both the clinical and genetic factors that put certain individuals at high risk for developing opioid use disorder (OUD) following use of POs for pain relief. With a greater understanding of important risk factors, physicians will be better able to identify patients at highest risk for developing OUD for whom non-opioid alternative therapies and treatments should be considered.

Methods: We are conducting a prospective observational study that aims to identify the clinical and genetic factors most stongly associated with OUD. The study design leverages an existing biobank that includes whole exome sequencing and array genotyping. The biobank is maintained within an integrated health system, allowing for the large-scale capture and integration of genetic and non-genetic data. Participants are enrolled into the health system biobank via informed consent and then into a second study that focuses on opioid medication use. Data capture includes validated self-report surveys measuring addiction severity, depression, anxiety, and nicotine use, as well as additional clinical, prescription, and brain imaging data extracted from electronic health records.

Discussion: We will harness this multimodal data capture to establish meaningful patient phenotypes in order to understand the genetic and non-genetic contributions to OUD.

Keywords: Addiction; Genetics; Opioid use disorder (OUD); Substance misuse.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
GaPO study visits, assessments, and data extraction flow chart
Fig. 2
Fig. 2
Relevant features of the Geisinger translational research infrastructure and study design of GaPO that allow for large scale genomic and phenotypic data capture
See this image and copyright information in PMC

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