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Review
. 2022 Feb;233(4):1613-1619.
doi: 10.1111/nph.17826. Epub 2021 Nov 16.

What does the distribution of fitness effects of new mutations reflect? Insights from plants

Jun Chen  1 , Thomas Bataillon  2 , Sylvain Glémin  3   4 , Martin Lascoux  4
Affiliations
Free article
Review

What does the distribution of fitness effects of new mutations reflect? Insights from plants

Jun Chen et al. New Phytol. 2022 Feb.
Free article

Abstract

The distribution of fitness effects (DFE) of new mutations plays a central role in molecular evolution. It is therefore crucial to be able to estimate it accurately from genomic data and to understand the factors that shape it. After a rapid overview of available methods to characterize the fitness effects of mutations, we review what is known on the factors affecting them in plants. Available data indicate that life history traits (e.g. mating system and longevity) have a major effect on the DFE. By contrast, the impact of demography within species appears to be more limited. These results remain to be confirmed, and methods to estimate the joint evolution of demography, life history traits, and the DFE need to be developed.

Keywords: demography; distribution of fitness effects; life history traits; mating systems; nearly neutral theory.

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References

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