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Comment
. 2021 Dec 6;218(12):e20211996.
doi: 10.1084/jem.20211996. Epub 2021 Oct 27.

Bone marrow runs the (bone) show

Gerard Karsenty  1
Affiliations
Comment

Bone marrow runs the (bone) show

Gerard Karsenty. J Exp Med. .

Abstract

In this issue of JEM, a paper by Kim et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211872), asking a simple question through a remarkable alliance of human and mouse genetics, demonstrates that a prevalent hematological condition can lead to osteoporosis. This work is important by virtue of the quality of its results and its implication for the relationship between bone and its marrow.

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Comment on

  • Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.
    Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Kim PG, et al. J Exp Med. 2021 Dec 6;218(12):e20211872. doi: 10.1084/jem.20211872. Epub 2021 Oct 26. J Exp Med. 2021. PMID: 34698806 Free PMC article.

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