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Editorial
. 2021 Dec 1;204(11):1241-1243.
doi: 10.1164/rccm.202109-2213ED.

COVID-19-related Acute Respiratory Distress Syndrome Subphenotypes and Differential Response to Corticosteroids: Time for More Precision?

Kiran Reddy  1 , Charles Corey Hardin  2 , Daniel Francis McAuley  1   3
Affiliations
Editorial

COVID-19-related Acute Respiratory Distress Syndrome Subphenotypes and Differential Response to Corticosteroids: Time for More Precision?

Kiran Reddy et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
A conceptual framework representing critical illness subphenotypes as continuous, rather than categorical, variables. A given individual might strongly allocate to a subphenotype by one classification method but may be indeterminate (in the uncertain area) in another classification schema, thereby residing on multiple points along the two lines representing class membership to class 1/class 2 and hyperinflammatory/hypoinflammatory. Continuous scores, rather than absolute class membership, may then be used to select patients most likely to benefit from intervention, perhaps taking into account multiple class membership scores. A number of intrinsic and extrinsic factors (represented on the scales in the middle of the diagram), such as transcriptomic changes, vaccination status, socioeconomic factors, and infection with a particular SARS-CoV-2 variant (in the examples of subphenotypes of coronavirus disease [COVID-19]), influence the individual’s position on multiple continuums. SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; VILI = ventilator-induced lung injury.
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References

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