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. 2021 Oct 27;21(1):551.
doi: 10.1186/s12903-021-01812-9.

Comparison of the sex hormones' serum level in women with recurrent aphthous stomatitis and healthy population: a cross-sectional study

Fatemeh Lavaee  1 , Zahra Ranjbar  2 , Mina Jalalian  3 , Mohammad Amin Amiri  3
Affiliations

Comparison of the sex hormones' serum level in women with recurrent aphthous stomatitis and healthy population: a cross-sectional study

Fatemeh Lavaee et al. BMC Oral Health. .

Abstract

Background: In this study, we aimed to evaluate the sex hormonal serum level in patients with recurrent aphthous stomatitis and compare them with healthy participants.

Methods: This cross-sectional study was done on patients with recurrent aphthous stomatitis who had referred to Shiraz Dental Faculty, Oral and Maxillofacial Medicine Department during 2018-2019. The non -menopause women with recurrence of at least 3 lesions per year were enrolled in this study. The mean serum level of FSH, LH, PRL (prolactin), testosterone, DHT (Dihydrotestosterone), DHEA-S (Dehydroepiandrosterone sulfate), estradiol and progesterone of 30 participants in each group of case and control were measured and compared. The data were analyzed by SPSS version 18 and independent T-test, Mann-Whitney U test, Spearman's correlation coefficient test, Chi-square test and Fisher's test.

Results: The mean serum level of DHEA-S in patients with recurrent aphthous stomatitis (RAS) was significantly lower than the control group (p value = 0.02). In addition to DHEA-S, the mean serum level of testosterone was lower in the evaluation group although this difference was not significant (p value = 0.057). Considering the effect of age on the mean serum level of sex hormones, our results revealed that only DHEA-S mean serum level was decreased by increasing the age of participants in patients with RAS (p value = 0.018). The number of participants with abnormal range of testosterone (p value < 0.0001) and progesterone (p value = 0.037) serum level was significantly more in patients with RAS. The frequency of RAS in a year did not show a significant relationship with the serum level of the evaluated hormones.

Conclusion: The patients with RAS had a lower serum level of DHEA-S. The mean serum level of testosterone and progesterone was significantly abnormal in RAS patients.

Keywords: Estradiol; FSH; LH; Prolactin; Recurrent aphthous stomatitis; Testosterone.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Balan U, Gonsalves N, Jose M, Girish K. Symptomatic changes of oral mucosa during normal hormonal turnover in healthy young menstruating women. J Contemp Dent Pract. 2012;13(2):178–181. doi: 10.5005/jp-journals-10024-1117. - DOI - PubMed
    1. Giannetti L, Murri ADD, Lo LM. Recurrent aphtous stomatitis. Minerva Stomatol. 2018;67(3):125–128. - PubMed
    1. Izakovicova Holla L, Valova S, Borilova Linhartova P, Bartova J, Petanova J, Kuklinek P, et al. Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 2017;46(10):1030–1035. - PubMed
    1. Suter VGA, Sjolund S, Bornstein MM. Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review. Lasers Med Sci. 2017;32(4):953–963. doi: 10.1007/s10103-017-2184-z. - DOI - PubMed
    1. González DA, Díaz BB, Pérez MdCR, Hernández AG, Chico BND, de León AC. Sex hormones and autoimmunity. Immunol Lett. 2010;133(1):6–13. doi: 10.1016/j.imlet.2010.07.001. - DOI - PubMed

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