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Comment
. 2021 Dec;21(12):759.
doi: 10.1038/s41577-021-00647-3.

APOL1 variants contribute to racial disparity in sepsis

Lucy Bird  1
Affiliations
Comment

APOL1 variants contribute to racial disparity in sepsis

Lucy Bird. Nat Rev Immunol. 2021 Dec.

Abstract

Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide sensing pathways.

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References

    1. Wu J, et al. APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis. Immunity. 2021 doi: 10.1016/j.immuni.2021.10.004. - DOI - PMC - PubMed