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. 1987 Apr;84(7):1978-80.
doi: 10.1073/pnas.84.7.1978.

Basic protein enhances the incorporation of DNA into lipid vesicles: model for the formation of primordial cells

D G Jay, W Gilbert

Basic protein enhances the incorporation of DNA into lipid vesicles: model for the formation of primordial cells

D G Jay et al. Proc Natl Acad Sci U S A. 1987 Apr.

Abstract

DNA can be encapsulated into lipid vesicles formed by sonication. The presence of a basic protein, lysozyme, enhances the incorporation 100-fold above the level expected by random trapping. This is demonstrated by the ability of the lipid vesicles to protect DNA from digestion with DNase. Such an enhancement of nuclei acid incorporation into vesicles by basic polypeptides and the sharply increased concentration of these macromolecules in the internal volume may have been advantageous in prebiotic evolution.

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References

    1. J Cell Biol. 1975 Aug;66(2):292-304 - PubMed
    1. J Mol Evol. 1982;18(3):203-6 - PubMed
    1. J Biol Chem. 1980 Nov 25;255(22):10681-6 - PubMed
    1. J Biol Chem. 1980 Nov 10;255(21):10431-5 - PubMed

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