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Review
. 2021 Oct 21;11(4):20458940211054304.
doi: 10.1177/20458940211054304. eCollection 2021 Oct-Dec.

Liver abnormalities in pulmonary arterial hypertension

Nils P Nickel  1 , Gian M Galura  2 , Marc J Zuckerman  2 , M Nawar Hakim  3 , Haider Alkhateeb  4 , Debabrata Mukherjee  4 , Eric D Austin  5 , Gustavo A Heresi  6
Affiliations
Review

Liver abnormalities in pulmonary arterial hypertension

Nils P Nickel et al. Pulm Circ. .

Abstract

Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease with high mortality. In recent years, it has been recognized that PAH is a multi-organ system disease, involving the systemic circulation, kidneys, skeletal muscles, and the central nervous system, among others. Right heart failure produces congestive hepatopathy, a disease state that has direct consequences on liver biochemistry, histology, and systemic glucose and lipid metabolism. This article aims to summarize the consequences of congestive hepatopathy with an emphasis on liver biochemistry, histology, and PAH-targeted therapy. Furthermore, PAH-specific changes in glucose and lipid metabolism will be discussed.

Keywords: lipid metabolism; liver; pulmonary arterial hypertension; venous congestion.

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Figures

Fig. 1.
Fig. 1.
Right heart failure and liver abnormalities in PAH.
Fig. 2.
Fig. 2.
Liver metabolism in patients with PAH.
See this image and copyright information in PMC

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