Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct 11:9:753931.
doi: 10.3389/fcell.2021.753931. eCollection 2021.

Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases

Yi-Li Zheng  1 , Ge Song  1 , Jia-Bao Guo  2 , Xuan Su  1 , Yu-Meng Chen  1 , Zheng Yang  1 , Pei-Jie Chen  1 , Xue-Qiang Wang  1   3
Affiliations
Review

Interactions Among lncRNA/circRNA, miRNA, and mRNA in Musculoskeletal Degenerative Diseases

Yi-Li Zheng et al. Front Cell Dev Biol. .

Abstract

Musculoskeletal degenerative diseases (MSDDs) are pathological conditions that affect muscle, bone, cartilage, joint and connective tissue, leading to physical and functional impairments in patients, mainly consist of osteoarthritis (OA), intervertebral disc degeneration (IDD), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are novel regulators of gene expression that play an important role in biological regulation, involving in chondrocyte proliferation and apoptosis, extracellular matrix degradation and peripheral blood mononuclear cell inflammation. Research on MSDD pathogenesis, especially on RA and AS, is still in its infancy and major knowledge gaps remain to be filled. The effects of lncRNA/circRNA-miRNA-mRNA axis on MSDD progression help us to fully understand their contribution to the dynamic cellular processes, provide the potential OA, IDD, RA and AS therapeutic strategies. Further studies are needed to explore the mutual regulatory mechanisms between lncRNA/circRNA regulation and effective therapeutic interventions in the pathology of MSDD.

Keywords: age-related disease; aging; circRNA; degenerative musculoskeletal disorders; lncRNA; miRNA; non-coding RNAs.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Example of altered lncRNA expression patterns and their biological effects in intervertebral disk degeneration. lncRNA, long non-coding RNA; ECM, extracellular matrix; MMP, matrix metallopeptidase; MAPK, mitogen-activated protein kinase; SMAD3, SMAD family member 3; LEF1, lymphoid enhancing factor-1; CCND1, cyclin D1; ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4; TRAF6, tumor necrosis factor receptor-associated factor 6; Notch1, Notch Receptor 1; Bcl-2, B cell lymphoma 2; ATG5, autophagy-related gene 5.
FIGURE 2
FIGURE 2
Example of altered circRNA expression patterns and their biological effects in osteoarthritis. circRNA, circular RNA; ECM, extracellular matrix; MMP, matrix metallopeptidase; NAMPT, Nicotinamide phosphoribosyltransferase; COX-2, cyclooxygenase-2; IL-6, interleukin-6; Col II, type II collagen; ERG, E26 transformation-specific-related gene; BAX, BCL2 associated X, apoptosis regulator; Bcl-2, B cell lymphoma 2; IGF1R, insulin-like growth factor 1 receptor; HIF, hypoxia inducible factor; BMP, bone morphogenetic protein.
FIGURE 3
FIGURE 3
Example of altered circRNA expression patterns and their biological effects in intervertebral disk degeneration. circRNA, circular RNA; ECM, extracellular matrix; SIRT1, silent mating type information regulation 2 homolog 1; XIAP, X linked inhibitor of-apoptosis protein; ERBB2, erb-b2 receptor tyrosine kinase 2; MMP, matrix metallopeptidase; Sox9, SRY-Box transcription factor 9; HDAC4, histone deacetylase 4; GSK-3β, glycogen synthase kinase-3β; SFRP1, secreted frizzled-related protein 1; CEMIP, cell migration-inducing hyaluronan binding protein; BTRC, beta-transducin repeat-containing protein.
See this image and copyright information in PMC

References

    1. Abbasifard M., Kamiab Z., Bagheri-Hosseinabadi Z., Sadeghi I. (2020). The role and function of long non-coding RNAs in osteoarthritis. Exp. Mol. Pathol. 114:104407. 10.1016/j.yexmp.2020.104407 - DOI - PubMed
    1. Ai D., Yu F. (2019). LncRNA DNM3OS promotes proliferation and inhibits apoptosis through modulating IGF1 expression by sponging MiR-126 in CHON-001 cells. Diagn. Pathol. 14:106. - PMC - PubMed
    1. Beermann J., Piccoli M. T., Viereck J., Thum T. (2016). Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches. Physiol. Rev. 96 1297–1325. 10.1152/physrev.00041.2015 - DOI - PubMed
    1. Cao L., Wang Y., Wang Q., Huang J. (2018). LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression. Biomed. Pharmacother. 106 1220–1226. 10.1016/j.biopha.2018.07.048 - DOI - PubMed
    1. Chen G., Liu T., Yu B., Wang B., Peng Q. (2020). CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373/HIF-1a axis. Cell Cycle 19 1696–1705. 10.1080/15384101.2020.1772545 - DOI - PMC - PubMed