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. 2021;3(3):133-139.
doi: 10.33696/immunology.3.090.

Efferocytosis and Anthrax: Implications for Bacterial Sepsis?

Joshua S Mytych  1   2 , Zijian Pan  1 , A Darise Farris  1   2
Affiliations

Efferocytosis and Anthrax: Implications for Bacterial Sepsis?

Joshua S Mytych et al. J Cell Immunol. 2021.
No abstract available

Keywords: Apoptotic cell clearance; Bacillus anthracis; Edema toxin; Efferocytosis; Sepsis.

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Conflict of interest statement

Disclosure Statement The authors declare no conflicts of interest or disclosures.

Figures

Figure 1:
Figure 1:
Proposed host-driven mechanism leading to defective efferocytosis. a) Under normal conditions apoptotic cells are efficiently cleared by macrophages that recognize, ingest, and process them b) Schematic representation of host DAMPs and proposed feed-back loop on efferocytosis from secondary necrotic cells. Uncleared apoptotic cells release various mediators (e.g. nuclear and cytosolic factors) that reduce the capacity of macrophages to efferocytose subsequent apoptotic cells, prolonging inefficient clearance and potentiating a pro-inflammatory response. Currently unknown are the mechanism(s) that lead to defects in the clearance of apoptotic cells. Figure was created with Biorender.com.
See this image and copyright information in PMC

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