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Randomized Controlled Trial
. 2022 Feb;49(2):134-143.
doi: 10.1111/jcpe.13567. Epub 2021 Nov 9.

Enamel matrix derivative as an adjunct to minimally invasive non-surgical treatment of intrabony defects: A randomized clinical trial

Styliani Anoixiadou  1 , Andreas Parashis  1   2 , Ioannis Vouros  1
Affiliations
Randomized Controlled Trial

Enamel matrix derivative as an adjunct to minimally invasive non-surgical treatment of intrabony defects: A randomized clinical trial

Styliani Anoixiadou et al. J Clin Periodontol. 2022 Feb.

Abstract

Aim: To compare the efficacy of minimally invasive non-surgical technique (MINST) with or without enamel matrix derivative (EMD) in the treatment of intrabony defects ≤7 mm.

Materials and methods: Thirty-six patients were randomly assigned to the two groups. The control group received MINST, while the experimental MINST+EMD. Clinical measurements were recorded at baseline and at 6 and 12 months, and radiographic measurements were made at baseline and 12 months.

Results: All subjects completed the study, 18 in each group. Significant improvements were observed in both groups at 12 months (p < .001) with no differences in mean PD reduction (4.0 ± 1.4 vs. 4.2 ± 1.7 mm), CAL gain (3.5 ± 1.4 vs. 3.4 ± 1.6 mm), and defect resolution (1.9 ± 1.1 vs. 1.8 ± 0.9 mm) for the MINST and the MINST+EMD groups, respectively (p > .05). A trend for greater pocket closure (PD ≤4 mm and no BoP) was achieved with the application of EMD (77.8% vs. 55.6% sites), particularly for sites with baseline PD ≤8 mm (92.3% vs. 69.2% sites), accompanied by an increased number of successful composite outcome results (61.1% vs. 44.4% sites).

Conclusions: MINST demonstrates significant improvements 12 months after treatment of intrabony defects ≤7 mm. The additional application of EMD does not further improve the mean clinical or radiographic outcomes. This study is registered in ClinicalTrials.gov (NCT03622255).

Keywords: (MeSH verified) enamel matrix proteins; intrabony defects; minimally invasive non-surgical procedures; periodontal debridement; periodontal pocket.

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References

REFERENCES

    1. Aimetti, M., Ferrarotti, F., Mariani, G. M., & Romano, F. (2017). A novel flapless approach versus minimally invasive surgery in periodontal regeneration with enamel matrix derivative proteins: A 24-month randomized controlled clinical trial. Clinical Oral Investigations, 21(1), 327-337. https://doi.org/10.1007/s00784-016-1795-2
    1. Claffey, N., Polyzois, I., & Ziaka, P. (2004). An overview of nonsurgical and surgical therapy. Periodontology 2000, 36, 35-44. https://doi.org/10.1111/j.1600-0757.2004.00073
    1. Cortellini, P. (2012). Minimally invasive surgical techniques in periodontal regeneration. The Journal of Evidence-Based Dental Practice, 12(3 SUPPL), 89-100. https://doi.org/10.1016/S1532-3382(12)70021-0
    1. Cortellini, P., Prato, G. P., & Tonetti, M. S. (1993). Periodontal regeneration of human Infrabony defects. I. Clinical measures. Journal of Periodontology, 64(4), 254-260. https://doi.org/10.1902/jop.1993.64.4.254
    1. Cortellini, P., & Tonetti, M. S. (2007). A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: A novel approach to limit morbidity. Journal of Clinical Periodontology, 34(1), 87-93. https://doi.org/10.1111/j.1600-051X.2006.01020.x

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