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. 2022 Feb;29(2):121-127.
doi: 10.1111/iju.14731. Epub 2021 Oct 27.

Incidence and survival variations of upper tract urothelial cancer in Taiwan (2001-2010)

Ming-Yen Lin  1   2 , Sheng-Wen Niu  3   4 , Wei-Ming Li  5   6   7 , Huei-Lan Lee  8 , Li-Tzong Chen  9   10   11 , Wen-Jeng Wu  5   6   7 , Shang-Jyh Hwang  1   2   4   12
Affiliations

Incidence and survival variations of upper tract urothelial cancer in Taiwan (2001-2010)

Ming-Yen Lin et al. Int J Urol. 2022 Feb.

Abstract

Objectives: To assess temporal patterns and regional differences in the incidence rate, and factors associated with survival of urinary tract urothelial carcinoma.

Methods: The medical records of 8830 patients with new diagnoses of urinary tract urothelial carcinoma in the years 2001-2010 were retrieved from Taiwan National databases. Temporal trends, regional disparity and related survival factors were evaluated using the Cochran-Armitage trend test, local Moran's I statistic and log-rank test, respectively.

Results: The annual urinary tract urothelial carcinoma incidence rates (standardized by age) were steady at approximately 3.14-3.41 per 100 000 person-years. Notably, women had a significantly higher annual urinary tract urothelial carcinoma incidence than men in most of the years studied (range of female-to-male annual standardized rate ratio: 2.08-3.25), and diabetes prevalence in urinary tract urothelial carcinoma increased significantly from 12.3% to 23.4% per year over the 10 years. High urinary tract urothelial carcinoma incidence cluster areas other than the latest endemic area of "blackfoot disease" were newly identified by local Moran's I statistic (P < 0.05). Furthermore, older age, male sex, end-stage kidney disease and more advanced tumor grade were associated with lower 5-year overall survival probabilities in the 2001-2015 cohort.

Conclusions: The incidence and survival of urinary tract urothelial carcinoma over the decade 2001-2010 were different according to population and regional features. Various urinary tract urothelial carcinoma screening, prevention, treatment and care plans should be developed depending on age, sex, comorbidity and area of residence.

Keywords: geographic variation; incidence; survival; trends; upper tract urothelial carcinoma.

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Sex‐specific incidence of UTUC by age in 2001–2010.
Fig. 2
Fig. 2
Trends in age‐standardized incidence rates for UTUC in 2001–2010. The annual incidence rate was standardized to the World Health Organization’s 2000 standard population.
Fig. 3
Fig. 3
Prevalence trend of the main comorbidity in patients with UTUC in 2001–2010. (a) DM and (b) ESKD.
Fig. 4
Fig. 4
Univariate local indicators of spatial association cluster maps for Taiwan UTUC incidence, 2001–2010. High‐high represents that a township with high UTUC incidence is surrounded by neighbors with high UTUC incidence; low‐low represents that a township with low UTUC incidence is surrounded by neighbors with low UTUC incidence; low‐high represents that a township with low UTUC incidence is surrounded by neighbors with high UTUC incidence; and high‐low represents that a township with high UTUC incidence is surrounded by neighbors with low UTUC incidence. The remaining 19 townships had no neighboring townships.
See this image and copyright information in PMC

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