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Review
. 2022 Feb;36(1):269-282.
doi: 10.1016/j.hoc.2021.08.011. Epub 2021 Oct 25.

Neurocognition and Health-Related Quality of Life Among Patients with Brain Tumors

Kyle Noll  1 , Amanda L King  2 , Linda Dirven  3 , Terri S Armstrong  4 , Martin J B Taphoorn  3 , Jeffrey S Wefel  5
Affiliations
Review

Neurocognition and Health-Related Quality of Life Among Patients with Brain Tumors

Kyle Noll et al. Hematol Oncol Clin North Am. 2022 Feb.

Abstract

Patients with brain tumors experience great symptom burden across various domains of functioning, with associated decreases in health-related quality of life and general well-being. Impaired neurocognitive functioning is among the primary concerns of these patients. Unfortunately, most patients will experience such impairment at some point in the disease. However, impaired neurocognitive functioning, symptom burden, and well-being vary according numerous patient-, tumor-, and treatment-related factors. Recent work has furthered our understanding of these contributors to patient functioning and health-related quality of life and also points to various potential targets for prevention and intervention strategies, though more efficacious treatments remain needed.

Keywords: Brain tumor; Neuro-oncology; Neurocognitive function; Neuropsychology; Quality of life.

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Conflict of interest statement

Disclosure J.S. Wefel, has consulting/advisory board relationships with Bayer, GT Medical Technologies, Juno, Novocure, and Vanquish Oncology.