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. 2021 Dec 31;59(1):2101932.
doi: 10.1183/13993003.01932-2021. Print 2022 Jan.

Resilience of the respiratory microbiome in controlled adult RSV challenge study

Leah Cuthbertson  1 , Phillip James  1 , Maximillian S Habibi  1 , Ryan S Thwaites  1 , Allan Paras  1 , Christopher Chiu  2 , Peter J M Openshaw  1 , William O C Cookson  1 , Miriam F Moffatt  3
Affiliations

Resilience of the respiratory microbiome in controlled adult RSV challenge study

Leah Cuthbertson et al. Eur Respir J. .

Abstract

This study of healthy adults revealed no major changes in the bacterial community of the respiratory tracts following RSV inoculation, suggesting that the adult respiratory microbial community is resilient to viral perturbations https://bit.ly/3AwnMc8

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Conflict of interest statement

Conflict of interest: L. Cuthbertson has nothing to disclose. Conflict of interest: P. James has nothing to disclose. Conflict of interest: M.S. Habibi has nothing to disclose. Conflict of interest: R.S. Thwaites has nothing to disclose. Conflict of interest: A. Paras has nothing to disclose. Conflict of interest: C. Chiu has nothing to disclose. Conflict of interest: P.J.M. Openshaw has nothing to disclose. Conflict of interest: W.O.C. Cookson has nothing to disclose. Conflict of interest: M.F. Moffatt has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Mean change in viral load (by qPCR), bacterial load (by qPCR) and alpha diversity (three measures Richness, Shannon, Simpson) over the course of the study for the three groups: clinical cold (infected), asymptomatic infected, and uninfected. Error bars represent the standard error of the mean.
See this image and copyright information in PMC

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