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Comment
. 2022 Jan 1;28(1):3-4.
doi: 10.1158/1078-0432.CCR-21-3409. Epub 2021 Oct 28.

Taming the Wild-Type Gastrointestinal Stromal Tumor: Improved Tissue Culture

Andrew M Blakely  1 , John W Glod  2 , Mary Frances Wedekind Malone  2
Affiliations
Comment

Taming the Wild-Type Gastrointestinal Stromal Tumor: Improved Tissue Culture

Andrew M Blakely et al. Clin Cancer Res. .

Abstract

Wild-type gastrointestinal stromal tumors (WT GIST) are most frequently characterized by succinate dehydrogenase (SDH) deficiency. Reliable ex vivo tumor models have been difficult to develop given the downstream metabolic effects of SDH deficiency. Improved tumor modeling approaches are needed to develop effective systemic treatment options for patients with WT GIST.See related article by Yebra et al., p. 187.

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References

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