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Comment
. 2021 Oct 28;6(1):373.
doi: 10.1038/s41392-021-00789-9.

Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response

Kerryn Elliott  1 , Jonas Nilsson  2   3 , Jimmy Van den Eynden  4
Affiliations
Comment

Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response

Kerryn Elliott et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Pharmacologic splicing modulation generates large numbers of highly immunogenic neoantigens which enhance immunotherapy-induced cancer cell death and survival. Box shows estimated amounts of mutation-derived neoantigens for comparison. Created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
    Lu SX, De Neef E, Thomas JD, Sabio E, Rousseau B, Gigoux M, Knorr DA, Greenbaum B, Elhanati Y, Hogg SJ, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham BH, Shah H, Chowell D, Gabel AM, Shen Y, Liu J, Jin J, Rhodes MC, Taylor RE, Molina H, Wolchok JD, Merghoub T, Diaz LA Jr, Abdel-Wahab O, Bradley RK. Lu SX, et al. Cell. 2021 Jul 22;184(15):4032-4047.e31. doi: 10.1016/j.cell.2021.05.038. Epub 2021 Jun 24. Cell. 2021. PMID: 34171309 Free PMC article.

References

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