Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

Shuai Liu^{1

2}, Cui-Shan Zhang^{1

2}, Xiao-Qian Ran^{3

2}, Xiao-Han Tang¹, Ya-Rong Guo⁴, Ying Yan⁵, Yong-Gang Yao^{3

2

6}, Xiao-Jiang Hao¹, Rong-Can Luo^{2

3}, Ying-Tong Di^{1

2}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. diyt@mail.kib.ac.cn.
² Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
³ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China. luorongcan@mail.kiz.ac.cn.
⁴ School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
⁵ Guizhou Chemical Drug Research and Development Engineering Technical Center, Guizhou Medicinal University, Guiyang 550004, China.
⁶ CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

PMID: 34714900
DOI: 10.1039/d1ob01927a

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

Shuai Liu et al. Org Biomol Chem. 2021.

. 2021 Nov 18;19(44):9637-9640.

doi: 10.1039/d1ob01927a.

Authors

Shuai Liu^{1

2}, Cui-Shan Zhang^{1

2}, Xiao-Qian Ran^{3

2}, Xiao-Han Tang¹, Ya-Rong Guo⁴, Ying Yan⁵, Yong-Gang Yao^{3

2

6}, Xiao-Jiang Hao¹, Rong-Can Luo^{2

3}, Ying-Tong Di^{1

2}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. diyt@mail.kib.ac.cn.
² Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China.
³ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China. luorongcan@mail.kiz.ac.cn.
⁴ School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
⁵ Guizhou Chemical Drug Research and Development Engineering Technical Center, Guizhou Medicinal University, Guiyang 550004, China.
⁶ CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

PMID: 34714900
DOI: 10.1039/d1ob01927a

Abstract

Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.

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Cited by

Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect.
Cai M, Bai XL, Zang HJ, Tang XH, Yan Y, Wan JJ, Peng MY, Liang H, Liu L, Guo F, Zhao PJ, Liao X, Di YT, Hao XJ. Cai M, et al. Int J Mol Sci. 2023 Nov 11;24(22):16196. doi: 10.3390/ijms242216196. Int J Mol Sci. 2023. PMID: 38003386 Free PMC article.

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Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

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Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

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