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. 2021 Oct 28;184(22):5503-5505.
doi: 10.1016/j.cell.2021.10.005.

Illuminating the path to DNA repair

Darshana Gupta  1 , Chase L Beisel  2
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Illuminating the path to DNA repair

Darshana Gupta et al. Cell. .
Free article

Abstract

Diverse DNA repair pathways correct ranging types of damage and play central roles in genome editing. In this issue of Cell, two publications leverage a new high-throughput screen that links pathway genes with the outcomes of repair, yielding mechanistic insights into the repair process as well as means to shape editing outcomes.

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Conflict of interest statement

Declaration of interests C.L.B. is a co-founder and scientific advisory board member of Locus Biosciences and a scientific advisory board member of Benson Hill. C.L.B. has filed provisional patent applications related to CRISPR-based editing. D.G. declares no competing interests.

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