Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec:168:103494.
doi: 10.1016/j.critrevonc.2021.103494. Epub 2021 Oct 26.

Receptor status of breast cancer diagnosed during pregnancy: A literature review

Carsten F J Bakhuis  1 , Britt B M Suelmann  2 , Carmen van Dooijeweert  3 , Sabine Linn  4 , Elsken van der Wall  1 , Paul J van Diest  3
Affiliations
Review

Receptor status of breast cancer diagnosed during pregnancy: A literature review

Carsten F J Bakhuis et al. Crit Rev Oncol Hematol. 2021 Dec.

Abstract

The definition of PABC is inconsistently given as either breast cancer diagnosed exclusively during pregnancy, or combined with breast cancer diagnosed within six months to five years after delivery, and sometimes even longer. The longer away from the delivery date breast cancer is diagnosed, the less clear this association with pregnancy may become. Therefore, breast cancer diagnosed during pregnancy (BCdP) may not necessarily be the same disease entity as PABC. This review aims to provide an overview of BCdP receptor status, as this has not been assessed before. BCdP tumors were predominantly ER negative (56.6 %), PR negative (57.2 %) or both ER and PR negative (47.9 %). Moreover, HER2-overexpression was seen in 33.2 % of BCdP patients and 27.6 % had triple negative disease. This predominantly ER and PR negative profile with more often HER2 overexpression is aggressive and distinct from non-pregnant similar-aged patients, warranting future comparative research.

Keywords: Breast cancer; Estrogen receptor; HER2; Pregnancy; Progesterone receptor.

PubMed Disclaimer