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. 2021 Oct 30;14(1):182.
doi: 10.1186/s13045-021-01201-3.

HLA alleles associated with asparaginase hypersensitivity in Chinese children

Gilbert T Chua #  1   2 , Jaime S Rosa Duque #  1   2 , Daniel Ka Leung Cheuk  1   2 , Alex Wing Kwan Leung  2   3 , Wilfred Hing Sang Wong  1 , Anthony Pak Yin Liu  1   2 , Pamela P W Lee  1   2 , Shau Yin Ha  1   2 , Alan Kwok Shing Chiang  1   2 , Marco Hok Kung Ho  1 , Wai Keung Chu  4 , Yuk Sing Chan  4 , Chun Wing Luk  2 , Alvin Siu Cheung Ling  2 , Mike Yat Wah Kwan  5 , Oscar Kuen Fong Yiu  1 , Ian Chi Kei Wong  6   7   8 , Yu Lung Lau  1   2 , Chi Kong Li  2   3 , Wing Hang Leung  1   2 , Godfrey Chi Fung Chan  1   2 , Patrick Ip  9   10 , Janette Kwok  11
Affiliations

HLA alleles associated with asparaginase hypersensitivity in Chinese children

Gilbert T Chua et al. J Hematol Oncol. .

Abstract

Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*46:01 (OR 3.8, 95% CI 1.4-10.1, p < 0.01) and DRB1*09:01 (OR 4.3, 95% CI 1.6-11.4, p < 0.01) were significantly associated with L-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*46:01 (adjusted OR 3.5, 95% 1.3-10.5, p = 0.02) and DRB1*09:01 (OR 4.4, 95% CI 1.6-13.3, p < 0.01)].

Keywords: Allergy; Asparaginase; Children; Chinese; Human leukocyte antigens; Hypersensitivity.

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Conflict of interest statement

The authors declare that they have no competing interests.

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