Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022

Abstract

The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global research in both academia and industry. With the explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up and updating its core database resources through big data archive, curation, integration and analysis. In the past year, efforts have been made to synthesize the growing data and knowledge, particularly in single-cell omics and precision medicine research, and a series of resources have been newly developed, updated and enhanced. Moreover, CNCB-NGDC has continued to daily update SARS-CoV-2 genome sequences, variants, haplotypes and literature. Particularly, OpenLB, an open library of bioscience, has been established by providing easy and open access to a substantial number of abstract texts from PubMed, bioRxiv and medRxiv. In addition, Database Commons is significantly updated by cataloguing a full list of global databases, and BLAST tools are newly deployed to provide online sequence search services. All these resources along with their services are publicly accessible at https://ngdc.cncb.ac.cn.

Figure 1.

Core database resources of CNCB-NGDC in terms of database categories. A full list of data resources, which contains links to each resource, is available at https://ngdc.cncb.ac.cn/databases.

Figure 2.

Statistics of data submissions. (A) Data statistics of BioProject and BioSample. (B) Data statistics of Experiments and Runs in GSA. (C) Timeline of data growth in GSA. (D) Statistics of genome assemblies in GWH. All statistics are frequently updated and publicly available at https://ngdc.cncb.ac.cn/bioproject, https://ngdc.cncb.ac.cn/biosample and https://ngdc.cncb.ac.cn/gsa and https://ngdc.cncb.ac.cn/gwh.