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. 2022 Jan 7;50(D1):D1282-D1294.
doi: 10.1093/nar/gkab1010.

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Simon D Harding  1 , Jane F Armstrong  1 , Elena Faccenda  1 , Christopher Southan  1 , Stephen P H Alexander  2 , Anthony P Davenport  3 , Adam J Pawson  1 , Michael Spedding  4 , Jamie A Davies  1 ; NC-IUPHAR
Affiliations

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

Simon D Harding et al. Nucleic Acids Res. .

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe expansion in content over nine database releases made during the last two years, which has focussed on three main areas of infection. The COVID-19 pandemic continues to have a major impact on health worldwide. GtoPdb has sought to support the wider research community to understand the pharmacology of emerging drug targets for SARS-CoV-2 as well as potential targets in the host to block viral entry and reduce the adverse effects of infection in patients with COVID-19. We describe how the database rapidly evolved to include a new family of Coronavirus proteins. Malaria remains a global threat to half the population of the world. Our database content continues to be enhanced through our collaboration with Medicines for Malaria Venture (MMV) on the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY (www.guidetomalariapharmacology.org). Antibiotic resistance is also a growing threat to global health. In response, we have extended our coverage of antibacterials in partnership with AntibioticDB.

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Figures

Figure 1.
Figure 1.
Google Analytics chart showing number of users accessing GtoPdb by country of origin from February 2020 to July 2021. Limited to those countries with over 10,000 total users during the time period.
Figure 2.
Figure 2.
Example of the main updates to GtoPdb Ligand Summary Pages, here showing the ligand baricitinib (www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7792).
Figure 3.
Figure 3.
GtoPdb ligand activity charts, showing example for baricitinib. The box plot charts are accessed from ligand summary pages and show activity data from GtoPdb and ChEMBL. Data are also presented in tabular format.
Figure 4.
Figure 4.
Guide to PHARMACOLOGY data in PubChem. Panel A shows the result of a main search on PubChem for ‘IUPHAR/BPS Guide to PHARMACOLOGY’. Panel B shows the result of searching PubChem substances for Guide to PHARMACOLOGY compounds, made available since 2020, tagged with our approved drug and antibody categories. Full query used is (((‘IUPHAR/BPS Guide to PHARMACOLOGY’[SourceName]) AND ‘gtopdb_approved’[Comment]) AND ‘gtopdb_antibody’[Comment]) AND (‘2020/01/01’[AvailableDate] : ‘3000’[AvailableDate]).
Figure 5.
Figure 5.
GtoPdb ligand summary page for rifampicin (www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2765) highlighting new specialist database outlinks to AntibioticDB and Reactome.
See this image and copyright information in PMC

References

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