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. 2022 Mar;29(13):19778-19789.
doi: 10.1007/s11356-021-17201-2. Epub 2021 Oct 31.

Propolis nanoparticles relieved the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia

Afaf D Abdelmagid  1 , Alshaimaa M Said  1 , Eman A Abdel Gawad  2 , Sara A Shalaby  1 , Mahmoud A O Dawood  3   4
Affiliations

Propolis nanoparticles relieved the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia

Afaf D Abdelmagid et al. Environ Sci Pollut Res Int. 2022 Mar.

Abstract

The risk of the waterborne toxicity caused by herbicides threatens the aquatic environment. In this study, propolis nanoparticles were shown to relieve the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia. The control group was fed a basal diet and maintained in a glyphosate-free water (control). Simultaneously, the other three groups were exposed to sublethal concentrations of glyphosate (0.6 mg/L) and fed diets containing 0 and 10 g propolis and 10 g propolis nanoparticles for 4 weeks. Nile tilapia exposed to glyphosate for 2 and 4 weeks exhibited a significant increase in serum alanine aminotransferase, aspartate aminotransferase, urea, and creatinine values compared to the control. After 2 and 4 weeks, fish exposed to glyphosate who were not fed propolis and propolis nanoparticles showed a significant reduction in total protein, albumin, and globulin levels, lysozyme activity, and total immunoglobulin levels. Nile tilapia exposed to glyphosate displayed a significant increase in blood glucose and cortisol concentrations after 2 and 4 weeks. Furthermore, liver and gill tissues from fish exposed to glyphosate exhibited a significant increase in malondialdehyde (MDA) concentrations. Conversely, a statistically significant decrease was observed in the liver and gill MDA levels and AChE activity of the groups treated with propolis and propolis nanoparticles compared to the groups exposed to glyphosate and fed the basal diet. Fish exposed to glyphosate for 2 and 4 weeks showed a significant decrease (p < 0.05) in hepatic and gill glutathione (GSH) concentration and white blood cell and red blood cell counts compared to the control group. Meanwhile, these parameters in groups fed propolis and propolis nanoparticles were markedly ameliorated compared to exposed fish fed the basal diet. Dietary supplementation of propolis nanoparticles is superior to supplementation of propolis in the normal form for protecting Nile tilapia from glyphosate toxicity.

Keywords: Clean aquaculture; Herbicides; Honeybee extracts; Nanotechnology; Stress markers.

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References

    1. Abd-El-Rhman AMM (2009) Antagonism of Aeromonas hydrophila by propolis and its effect on the performance of Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol 27:454–459
    1. Abd El-Gawad EA, Hamid OMA (2014) Effect of vitamin C dietary supplementation in reducing the alterations induced by fenitrothion in Oreochromis niloticus. Fish Physiol Biochem 40:787–796
    1. Abdel-Warith A-WA, Younis EM, Al-Asgah NA, Gewaily MS, El-Tonoby SM, Dawood MAO 2021 Role of fucoidan on the growth behavior and blood metabolites and toxic effects of atrazine in Nile tilapia Oreochromis niloticus (Linnaeus, 1758). Animals 11
    1. Abdelmagid AD, El Asely AM, Said AM (2021) Evaluation of Foeniculum vulgare impact on glyphosate hepato-toxicity in Nile tilapia: biochemical, molecular and histopathological study. Aquac Res 52:5397–5406
    1. Acar Ü (2018) Effects of diet supplemented with ethanolic extract of propolis on growth performance, hematological and serum biochemical parameters and disease resistance of Mozambique tilapia (Oreochromis mossambicus) against Streptococcus iniae. Aquaculture 495:339–344

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