Compatibility of FIASMA Pharmacokinetics With Study End Points?

Pascal Le Corre^{1

2

3}, Gwenolé Loas^{4

5}

Affiliations

¹ Pôle Pharmacie, Service Hospitalo-Universitaire de Pharmacie, CHU de Rennes, Rennes, France.
² CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France.
³ Laboratoire de Biopharmacie et Pharmacie Clinique, Faculté de Pharmacie, Université de Rennes 1, Rennes, France.
⁴ Department of Psychiatry, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium.
⁵ Research Unit (ULB 266), Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium.

Comment

Pascal Le Corre et al. Clin Pharmacol Ther. 2022 Feb.

. 2022 Feb;111(2):353.

doi: 10.1002/cpt.2442. Epub 2021 Oct 31.

Pascal Le Corre^{1

2

3}, Gwenolé Loas^{4

5}

¹ Pôle Pharmacie, Service Hospitalo-Universitaire de Pharmacie, CHU de Rennes, Rennes, France.
² CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, Environnement et travail) - UMR_S 1085, Univ Rennes, Rennes, France.
³ Laboratoire de Biopharmacie et Pharmacie Clinique, Faculté de Pharmacie, Université de Rennes 1, Rennes, France.
⁴ Department of Psychiatry, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium.
⁵ Research Unit (ULB 266), Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium.

No abstract available

Comment on

Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study.
Hoertel N, Sánchez-Rico M, Gulbins E, Kornhuber J, Carpinteiro A, Lenze EJ, Reiersen AM, Abellán M, de la Muela P, Vernet R, Blanco C, Cougoule C, Beeker N, Neuraz A, Gorwood P, Alvarado JM, Meneton P, Limosin F; AP-HP / Université de Paris / INSERM COVID-19 research collaboration, AP-HP COVID CDR Initiative, “Entrepôt de Données de Santé” AP-HP Consortium. Hoertel N, et al. Clin Pharmacol Ther. 2021 Dec;110(6):1498-1511. doi: 10.1002/cpt.2317. Epub 2021 Jul 2. Clin Pharmacol Ther. 2021. PMID: 34050932 Free PMC article.

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1. Loas, G. & Le Corre, P. Update on functional inhibitors of acid sphingomyelinase (FIASMAs) in SARS-CoV-2 Infection. Pharmaceuticals (Basel) 14, 691 (2021).
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