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Review
. 2021 Nov 1;9(1):33.
doi: 10.1186/s40345-021-00237-1.

Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review

Rosie H Taylor  1 , Andrea Ulrichsen  1 , Allan H Young  1   2 , Rebecca Strawbridge  3
Affiliations
Review

Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review

Rosie H Taylor et al. Int J Bipolar Disord. .

Abstract

Objectives: The early pathogenesis and precursors of Bipolar Disorder (BD) are poorly understood. There is some cross-sectional and retrospective evidence of affective lability as a predictor of BD, but this is subject to recall biases. The present review synthesises the prospective evidence examining affective lability and the subsequent development of BD at follow-up.

Methods: The authors performed a systematic search of PubMed, PsycInfo and Embase (1960-June 2020) and conducted hand searches to identify studies assessing affective lability (according to a conceptually-inclusive definition) at baseline assessment in individuals without a BD diagnosis, and a longitudinal follow-up assessment of bipolar (spectrum) disorders. Results are reported according to the PRISMA guidelines, and the synthesis without meta-analysis (SWiM) reporting guidelines were used to strengthen the narrative synthesis. The Newcastle-Ottawa Scale was used to assess risk of bias (ROB).

Results: 11 articles describing 10 studies were included. Being identified as having affective lability at baseline was associated with an increased rate of bipolar diagnoses at follow-up; this association was statistically significant in six of eight studies assessing BD type I/II at follow-up and in all four studies assessing for bipolar spectrum disorder (BSD) criteria. Most studies received a 'fair' or 'poor' ROB grade.

Conclusions: Despite a paucity of studies, an overall association between prospectively-identified affective lability and a later diagnosis of BD or BSD is apparent with relative consistency between studies. This association and further longitudinal studies could inform future clinical screening of those who may be at risk of BD, with the potential to improve diagnostic accuracy and facilitate early intervention.

Keywords: Affective lability; Bipolar disorder; Bipolar spectrum; Mood instability; Predictor; Prospective; Risk-factor; Systematic review.

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Conflict of interest statement

RS declares an honorarium from Lundbeck. AHY declares honoraria for speaking from Astra Zeneca, Lundbeck, Eli Lilly, Sunovion; honoraria for consulting from Allergan, Livanova and Lundbeck, Sunovion, Janssen; and research grant support from Janssen. AU and RHT have no conflicts of interest or financial disclosures to report.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram of the study selection process. Study flow diagram showing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. BD = bipolar disorder
See this image and copyright information in PMC

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