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. 2022 Mar;291(3):380-383.
doi: 10.1111/joim.13408. Epub 2021 Nov 1.

Effectiveness of REGEN-COV antibody cocktail against the B.1.617.2 (delta) variant of SARS-CoV-2: A cohort study

Jagadeesh Kumar V  1 , Sofia Banu  2   3 , Mitnala Sasikala  4 , Kishore V L Parsa  5 , Divya Tej Sowpati  2 , Rupali Yadav  5 , Karthik Bharadwaj Tallapaka  2 , Archana Bharadwaj Siva  2 , Ravikanth Vishnubhotla  4 , G V Rao  1 , Duvvur Nageshwar Reddy  1
Affiliations

Effectiveness of REGEN-COV antibody cocktail against the B.1.617.2 (delta) variant of SARS-CoV-2: A cohort study

Jagadeesh Kumar V et al. J Intern Med. 2022 Mar.
No abstract available

Keywords: SARS-CoV-2; pulmonary medicine; treatments.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
(a) A stacked bar plot representing the proportions of various SARS‐CoV‐2 lineages in antibody‐treated (mAb) and standard of care‐treated groups (SOC). The total number of genomes in a group is indicated on the top of the bar. (b) Percentage of individuals with positive RT‐PCR for SARS‐CoV‐2 and symptoms on Day 7 after the treatment. (c) Resolution of symptoms from Days 0 to 7 of treatment. (d) In vitro neutralization of pseudoviruses, including the total spike protein of SARS‐CoV‐2. (e) Comparison of Ct values of RdRp and N gene within the two groups. The rate of change in Ct values between the mAb and SOC groups was fitted using a linear model, and statistical significance was calculated using paired t‐test. **p = 0.0006; ****p = 0.0003.
See this image and copyright information in PMC

References

    1. Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, et al. REGN‐COV2, a neutralizing antibody cocktail, in outpatients with Covid‐19. N Engl J Med. 2021;384(3):238‐51. - PMC - PubMed
    1. O'Brien MP, Forleo‐Neto E, Musser BJ, Isa F, Chan K‐C, Sarkar N, et al. Subcutaneous REGEN‐COV antibody combination to prevent Covid‐19. N Engl J Med. 2021;385:1184–95. 10.1056/NEJMoa2109682 - DOI - PMC - PubMed
    1. Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 2014;30:2114–20. - PMC - PubMed
    1. Kim D, Paggi JM, Park C, Bennett C, Salzberg SL. Graph‐based genome alignment and genotyping with HISAT2 and HISAT‐genotype. Nat Biotechnol. 2019;37:907–15. - PMC - PubMed
    1. Hadfield J, Megill C, Bell SM, Huddleston J, Potter B, Callender C, et al. Nextstrain: real‐time tracking of pathogen evolution. Bioinformatics 2018;34:4121–3. - PMC - PubMed

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