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. 2021 Dec;78(6):1750-1759.
doi: 10.1161/HYPERTENSIONAHA.121.17875. Epub 2021 Nov 1.

Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

Michael A Francisco #  1   2 , Joshua F Lee #  1   2 , Zachary Barrett-O'Keefe  3   2 , H Jonathan Groot  3   2 , Stephen M Ratchford  2   4 , Kanokwan Bunsawat  1 , Jeremy K Alpenglow  2 , John J Ryan  1 , Jose N Nativi  1 , Russell S Richardson  1   3   2 , D Walter Wray  1   3   2
Affiliations

Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

Michael A Francisco et al. Hypertension. 2021 Dec.

Abstract

[Figure: see text].

Keywords: biomarkers; heart failure; hyperemia; inflammation; muscles.

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Conflict of interest statement

Disclosures

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

FIGURE 1:
FIGURE 1:
Panel A: Changes in leg blood flow during 1 minute of passive leg movement in controls and patients with HFpEF. Area under the curve (AUC) was calculated as the summed second-by-second values during passive movement. Panel B: Peak change in leg blood flow achieved during 1 minute of passive leg movement in controls and patients with HFpEF. *Significantly different than control, P < 0.05. HFpEF n = 43; Control n = 39. Data are mean ± SEM
FIGURE 2:
FIGURE 2:
Panel A: Changes in leg vascular conductance during 1 minute of passive leg movement in controls and patients with HFpEF. Area under the curve (AUC) was calculated as the summed second-by-second values during passive movement. Panel B: Peak change in leg vascular conductance achieved during 1 minute of passive leg movement in controls and patients with HFpEF. *Significantly different than control, P < 0.05. HFpEF n = 40; Control n = 35. Data are mean ± SEM
FIGURE 3:
FIGURE 3:
Serum biomarkers of inflammation, as assessed by C-reactive protein (panel A), Tumor Nercrosis Factor-α (panel B), and Interleukin-6 (panel C) in controls and patients with HFpEF. * Significantly different than control, P < 0.05. HFpEF n = 27; Control n = 35. Data are mean ± SEM
FIGURE 4:
FIGURE 4:
Serum biomarkers of oxidative damage, as assessed by protein carbonyl (panel A, HFpEF n = 26; Control n = 33) and malondialdehyde (panel B, HFpEF n = 27; Control n = 35) in controls and patients with HFpEF. * Significantly different than control, P < 0.05. Data are mean ± SEM
See this image and copyright information in PMC

References

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