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. 2021 May-Aug;15(2):78-85.
doi: 10.5005/jp-journals-10078-1305.

Ocular Perfusion Pressure and Severity of Glaucoma: Is There a Link?

T W Ch'ng  1 , C Y Chua  2 , M A Ummi Kalsom  3 , Y Azhany  4 , Vhm Gong  3 , Ahg Rasool  5 , A T Liza-Sharmini  4
Affiliations

Ocular Perfusion Pressure and Severity of Glaucoma: Is There a Link?

T W Ch'ng et al. J Curr Glaucoma Pract. 2021 May-Aug.

Abstract

Aim and objective: To establish the association between 12-month inter-visits ocular perfusion pressure (OPP) and severity of glaucoma.

Materials and methods: A total of 164 eyes (60 primary open-angle glaucoma, 52 normal-tension glaucoma, and 52 primary angle-closure glaucoma) of 164 patients were analyzed in this prospective cohort study. Patients who demonstrated good compliance to treatment were recruited. The severity of glaucoma was stratified according to the Advanced Glaucoma Intervention Study (AGIS) score based on reliable and reproducible visual field analysis at baseline. OPP was obtained at baseline and a 3-monthly follow-up visit over a 12-month duration. The pattern and fluctuation of mean OPP were studied. Repetitive measure ANOVA and one-way ANOVA were used for statistical analysis.

Results: The inter-visits mean OPP (p = 0.010), systolic OPP (p = 0.020), diastolic OPP (p = 0.010), systolic blood pressure (p = 0.040), and diastolic blood pressure (p = 0.006) showed significant difference with severity of glaucoma. There was no significant difference between mean inter-visits intraocular pressure (IOP) and severity of glaucoma (p = 0.410). The end-stage glaucoma group had the lowest mean OPP and widest inter-visit mean OPP fluctuation. Early and mild glaucoma patients demonstrated higher mean OPP compared with moderate, severe, and end-stage glaucoma.

Conclusion: There is a significant association between OPP and the severity of glaucoma. Balancing blood pressure and IOP is important in optimizing adequate perfusion and prevent further damage to the optic nerve head.

How to cite this article: Ch'ng TW, Chua CY, Ummi Kalsom MA, et al. Ocular Perfusion Pressure and Severity of Glaucoma: Is There a Link? J Curr Glaucoma Pract 2021;15(2):78-85.

Keywords: Blood pressure; Intraocular pressure; Ocular perfusion pressure; Severity of glaucoma.

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Conflict of interest statement

Source of support: This study is supported by the Research University Grant Universiti Sains Malaysia 1001/PPSP/812101. Conflict of interest: None

Figures

Figs 1A to C
Figs 1A to C
Mean OPP and severity of AGIS score
Fig. 2
Fig. 2
Mean inter-visits IOP and severity of glaucoma
Figs 3A and B
Figs 3A and B
Mean IOP difference between follow-up visits according to severity of AGIS score. (A) Mean systolic BP according to severity of AGIS score; (B) Mean diastolic BP according to severity of AGIS score
See this image and copyright information in PMC

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