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. 2021 Oct 23:14:1541-1549.
doi: 10.2147/CCID.S333288. eCollection 2021.

Association Between Daily Dietary Eicosatetraenoic Acid Intake and the Lower Risk of Psoriasis in American Adults

Jipang Zhan  1 , Xuhua Tang  1 , Fang Wang  1 , Jiande Han  1
Affiliations

Association Between Daily Dietary Eicosatetraenoic Acid Intake and the Lower Risk of Psoriasis in American Adults

Jipang Zhan et al. Clin Cosmet Investig Dermatol. .

Abstract

Purpose: Unlike eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the relationship between eicosatetraenoic acid (ETA) and psoriasis remains unclear. Therefore, We performed a cross-sectional study in the general American population to investigate the association between daily dietary ETA, EPA, and DHA intake and the risk of psoriasis.

Participants and methods: This study applied data from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2009-2014. Dietary n3 polyunsaturated fatty acids (PUFA) were calculated based on two 24-hour dietary recall interviews. We defined psoriasis by responding to the question "Have you ever been told by a doctor or other health care professional that you had psoriasis?". Multivariable logistic regression analysis, trend tests, subgroup analysis, and interaction tests were used to evaluate the associations of ETA, EPA, and DHA intake with the risk of psoriasis, respectively.

Results: A total of 15,733 participants were included in this study. In our optimal multivariate-adjusted model, the odds ratio (OR) with 95% confidence interval (CI) of psoriasis were 0.30 (0.12, 0.88), 1.92 (0.78, 4.74), 1.28 (0.72, 2.27) for daily dietary ETA, EPA, and DHA intake, respectively. Trend tests showed a dose-effect relationship between daily dietary ETA intake and the lower risk of psoriasis. Subgroup analysis and tests for interaction showed that the association was stable in different subgroups.

Conclusion: Our study revealed that there might be a dose-effect association of daily dietary ETA intake with the lower risk of psoriasis in American adults.

Keywords: NHANES; diet; eicosatetraenoic acid; long-chain n3 polyunsaturated fatty acid; psoriasis.

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Conflict of interest statement

All authors declare no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Possible biosynthesis and metabolic pathway of long-chain n3 PUFA.
Figure 2
Figure 2
Flowchart of the screening process for the eligible participants selection from National Centre for Health Statistics (NHANES).
Figure 3
Figure 3
Smooth curve fittings show the relationship between daily dietary eicosatetraenoic acid (ETA, 20:4 n-3) intake and the risk of psoriasis overall (A) and within all subgroups (B–I). The red line presents the OR value of the association of ETA and psoriasis, and the blue lines present the 95% confidence interval (A). Smooth curve fittings from (B–I) show the association in different subgroups stratified by each covariate, and each line presents the OR value of the association without a 95% confidence interval. All smooth curve fittings show that the risk of psoriasis decreased linearly with the increase in daily dietary ETA intake overall and within all subgroups. The association was adjusted for gender, age, veteran, marital status, PIR, BMI, drinking alcohol, smoking except the stratified covariate.
See this image and copyright information in PMC

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