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Review
. 2021 Oct 14:15:691016.
doi: 10.3389/fnins.2021.691016. eCollection 2021.

Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer's Disease

Ingar Olsen  1
Affiliations
Review

Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer's Disease

Ingar Olsen. Front Neurosci. .

Abstract

"Chronic" periodontitis and its keystone pathogen Porphyromonas gingivalis have repeatedly been associated with Alzheimer's disease (AD). Pathological hallmarks in AD are brain accumulations of amyloid-beta and neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. In addition, neuroinflammation induced by P. gingivalis has increasingly been recognized as a factor in the pathogenesis of AD. The present mini-review discusses possible mechanisms for the induction of neuroinflammation by P. gingivalis in AD, involving factors such as pro-inflammatory mediators, amyloid-beta, tau, microglia, cathepsin B, and protein kinase R. Inflammagens of P. gingivalis such as lipopolysaccharide and gingipains are also discussed.

Keywords: amyloid-beta; cathepsin B; gingipains; lipopolysaccharide; microglia; protein kinase R; tau.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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