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Review
. 2021 Oct 15;13(10):1453-1465.
doi: 10.4251/wjgo.v13.i10.1453.

Radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma

Laurent Quéro  1 , Mouna Labidi  1 , Marc Bollet  2 , Côme Bommier  3 , Sophie Guillerm  1 , Christophe Hennequin  1 , Catherine Thieblemont  3
Affiliations
Review

Radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma

Laurent Quéro et al. World J Gastrointest Oncol. .

Abstract

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease which is often associated with Helicobacter pylori (H. pylori) infection. First-line treatment of stage IE and IIE localized gastric MALT lymphoma is based on the eradication of H. pylori. The presence of H. pylori resistance factors such as translocation t (11;18), peri-gastric lymph node involvement and the degree of tumor infiltration of the gastric wall; or lack of response to antibiotic therapy are two main indications to treat with definitive radiotherapy (RT). RT is an effective treatment in localized gastric MALT lymphoma. A moderate dose of 30 Gy allows a high cure rate while being well tolerated. After treatment, regular gastric endoscopic follow-up is necessary to detect a potential occurrence of gastric adenocarcinoma.

Keywords: Helicobacter pylori; Lymphoma; MALT; Mucosa-associated lymphoid tissue; Radiotherapy; Review.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.

Figures

Figure 1
Figure 1
Prevalence of Helicobacter pylori infection in gastric marginal zone lymphoma. MALT: Mucosa-associated lymphoid tissue.
Figure 2
Figure 2
Gastric mucosa-associated lymphoid tissue lymphoma therapeutic algorithm. HP: Helicobacter pylori.
Figure 3
Figure 3
Example of dose distribution using volumetric modulated arc therapy in gastric mucosa-associated lymphoid tissue lymphoma.
See this image and copyright information in PMC

References

    1. Zucca E, Bertoni F. The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance. Blood. 2016;127:2082–2092. - PubMed
    1. Khalili M, Sakhaee E, Aflatoonian MR, Abdollahpour G, Tabrizi SS, Damaneh EM, Hossini-Nasab S. Seroprevalence of bovine leptospiral antibodies by microscopic agglutination test in Southeast of Iran. Asian Pac J Trop Biomed. 2014;4:354–357. - PMC - PubMed
    1. NIH SEER Preliminary Cancer Incidence Rate Estimates for 2017, and diagnosis years 2000 to 2017: Cancer Stat Facts: Non-Hodgkin Lymphoma. Surveillance Epidemiology and End Results Program: National Cancer Institute Bethesda MD, 2020. [cited 10 February 2021]. Available from: https://seer.cancer.gov/statistics/preliminary-estimates/
    1. Müller AM, Ihorst G, Mertelsmann R, Engelhardt M. Epidemiology of non-Hodgkin's lymphoma (NHL): trends, geographic distribution, and etiology. Ann Hematol. 2005;84:1–12. - PubMed
    1. Thieblemont C, Cascione L, Conconi A, Kiesewetter B, Raderer M, Gaidano G, Martelli M, Laszlo D, Coiffier B, Lopez Guillermo A, Torri V, Cavalli F, Johnson PW, Zucca E. A MALT lymphoma prognostic index. Blood. 2017;130:1409–1417. - PubMed