Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Oct 25;9(10):e05017.
doi: 10.1002/ccr3.5017. eCollection 2021 Oct.

Prolonged ventricular pause associated with ticagrelor use: A case report

Alaa Rahhal  1 , Amer Aljundi  1 , Sara Saeed Ibrahim Mohamed  2 , Muhammad Awais Arif  3 , Abdul Rahman Arabi  3
Affiliations
Case Reports

Prolonged ventricular pause associated with ticagrelor use: A case report

Alaa Rahhal et al. Clin Case Rep. .

Abstract

Case: We report a case of a 76-year-old female who presented with non-ST elevation myocardial infarction and developed a 22-second ventricular pause with ticagrelor that did not recur after shifting to clopidogrel. Based on the Naranjo algorithm, the likelihood that our patient's prolonged ventricular pause was due to ticagrelor exposure was probable.

Conclusion: Ticagrelor use is associated with prolonged ventricular pauses, warranting close monitoring, particularly during the first week of therapy.

Keywords: adverse drug reaction; ticagrelor; ventricular pause.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

FIGURE 1
FIGURE 1
T wave inversion in anterolateral leads (V3–V6)
FIGURE 2
FIGURE 2
A 22‐s pause on telemetry
See this image and copyright information in PMC

References

    1. Deeks ED. Ticagrelor: a review of its use in the management of acute coronary syndromes. Drugs. 2011;71(7):909‐933. 10.2165/11206850-000000000-00000 - DOI - PubMed
    1. Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045‐1057. 10.1056/NEJMoa0904327 - DOI - PubMed
    1. Nicol M, Deblaise J, Choussat R, Dubourg O, Mansencal N. Side effects of ticagrelor: sinus node dysfunction with ventricular pause. Int J Cardiol. 2015;15(191):56‐57. 10.1016/j.ijcard.2015.04.198 - DOI - PubMed
    1. Low A, Leong K, Sharma A, Oqueli E. Ticagrelor‐associated ventricular pauses: a case report and literature review. Eur Heart J Case Rep. 2018;3(1):yty156. 10.1093/ehjcr/yty156 - DOI - PMC - PubMed
    1. Cannon CP, Husted S, Harrington RA, et al. Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non‐ST‐segment elevation acute coronary syndrome: primary results of the DISPERSE‐2 tri. J Am Coll Cardiol. 2007;50(19):1844‐1851. 10.1016/j.jacc.2007.07.053 - DOI - PubMed

Publication types

LinkOut - more resources