Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct 10;19(9):761-772.
doi: 10.18502/ijrm.v19i9.9708. eCollection 2021 Sep.

Luteal-phase support in assisted reproductive technology: An ongoing challenge

Saeideh Dashti  1 , Maryam Eftekhar  1
Affiliations
Review

Luteal-phase support in assisted reproductive technology: An ongoing challenge

Saeideh Dashti et al. Int J Reprod Biomed. .

Abstract

It has been shown that in controlled ovarian hyper stimulation cycles, defective luteal phase is common. There are many protocols for improving pregnancy outcomes in women undergoing fresh and frozen in vitro fertilization cycles. These approaches include progesterone supplements, human chorionic gonadotropin, estradiol, gonadotropin-releasing hormone agonist, and recombinant luteinizing hormone. The main challenge is luteal-phase support (LPS) in cycles with gonadotropin-releasing hormone agonist triggering. There is still controversy about the optimal component and time for starting LPS in assisted reproductive technology cycles. This review aims to summarize the various protocols suggested for LPS in in vitro fertilization cycles.

Keywords: GnRH agonist; HCG; IVF; Progesterone; Recombinant LH.; Luteal-phase support.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

References

    1. Practice Committee of the American Society for Reproductive Medicine Current clinical irrelevance of luteal phase deficiency: A committee opinion. Fertil Steril 2015; 103: e27–e32. - PubMed
    1. Andersen CY, Fischer R, Giorgione V, Kelsey ThW. Micro-dose hCG as luteal phase support without exogenous progesterone administration: Mathematical modelling of the hCG concentration in circulation and initial clinical experience. J Assist Reprod Genet. 2016;33:1311–1318. - PMC - PubMed
    1. Casper RF, Yanushpolsky EH. Optimal endometrial preparation for frozen embryo transfer cycles: Window of implantation and progesterone support. Fertil Steril. 2016;105:867–872. - PubMed
    1. Razieh DF, Maryam AR, Nasim T. Beneficial effect of luteal-phase gonadotropin-releasing hormone agonist administration on implantation rate afterintracytoplasmic sperm injection. Taiwan J Obstet Gynecol. 2009;48:245–248. - PubMed
    1. Fatemi HM. Simplifying luteal phase support in stimulated assisted reproduction cycles. Fertil Steril. 2018;110:1035–1036. - PubMed

LinkOut - more resources