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. 2020 Oct 28;3(6):1427-1429.
doi: 10.1021/acsptsci.0c00167. eCollection 2020 Dec 11.

Rising Academic Contributions to Drug Development: Evidence of Vigor or Trauma?

Michael S Kinch  1 , Caitlin Horn  1 , Zachary Kraft  1 , Tyler Schwartz  1
Affiliations

Rising Academic Contributions to Drug Development: Evidence of Vigor or Trauma?

Michael S Kinch et al. ACS Pharmacol Transl Sci. .

Abstract

We analyzed therapeutic areas most commonly targeted by academia since 2001, finding a domination of certain oncology and infectious diseases. These findings raise important questions about whether this trend reflects an expanded opportunity arising from academic research or a troubling sign of an industry struggling with the challenges of innovation.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Academic contributions to oncology indications. Shown is a breakout of “neoplasm” drugs on a percent basis that were approved by FDA between 2001 and 2019 and listed as having academic inventors or founders based upon analyses of the FDA Orange Book. Also shown are those oncology-related subheadings with particularly high participation of NIH-funded inventors or founders.
Figure 2
Figure 2
Rise in academic-backed “neoplasm” drugs over time. Shown is the three-year running average of new molecular entities which were classified in the FDA Orange Book as having inventors from academia or companies founded by academics within 10 years of the approval.
See this image and copyright information in PMC

References

    1. Thorp H, and Goldstein B. (2013) Engines of Innovation, UNC Press, Chapel Hill.
    1. Kinch M. S.; Horn C.; Kraft Z.; Schwartz T. (2020) Expanding roles for academic entrepreneurship in drug discovery. Drug Discovery Today 10.1016/j.drudis.2020.09.004. - DOI - PMC - PubMed
    1. NIH , Welcome to Medical Subject Headings (2020) https://www.nlm.nih.gov/mesh/meshhome.html(accessed 2020-10-12).
    1. Mazzucato M. (2018) The Entrepreneurial State, Penguin, New York.

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