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. 2022 Jan;4(1):e11-e13.
doi: 10.1016/S2665-9913(21)00328-3. Epub 2021 Oct 26.

Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses

Affiliations

Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses

Kristin Schmiedeberg et al. Lancet Rheumatol. 2022 Jan.
No abstract available

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Conflict of interest statement

KS contributed to project administration, investigation, formal analysis, visualisation, and review and editing of the report. NV and SP were involved in investigation, formal analysis, and development of methodology. BL contributed to conceptualisation, investigation, and formal analysis. WCA was involved in investigation and development of methodology. JvK contributed to conceptualisation, investigation, and review and editing of the report. AR-R was the project lead, and was involved in conceptualisation, writing the original draft of the report, investigation, and formal analysis. KS reports support for travel or meeting attendance from AbbVie Germany. WCA reports grants from the Gottfried & Julia Bangerter-Rhyner Stiftung, FUNGINOS, and the Swiss National Science Foundation; an internal grant from Kantonsspital St Gallen; honoraria from Pfizer and Medscape; and compensation for participation on a data safety monitoring board from Merck Sharp & Dohme and Sanofi. JvK reports honoraria from AbbVie, Bristol Myers Squibb (BMS), Boehringer-lngelheim, GlaxoSmithKline, Menarini, Novartis, Pfizer, and Sanofi. AR-R reports consulting fees from AbbVie, Gilead, Lilly, BMS, and Sanofi; honoraria from AbbVie, Pfizer, Sanofi, UCB, BMS, Lilly, Gilead, and Roche; payment for expert testimony from AbbVie and Gilead; support for travel or meeting attendance from Sanofi, Roche, and AbbVie; and compensation for participation on a data safety monitoring board from R-Pharm. All other authors declare no competing interests.

Figures

Figure
Figure
Anti-SARS-CoV-2 S1 serum antibodies from patients with rheumatoid arthritis Patients with rheumatoid arthritis eligible for an additional vaccine dose (n=17) before and 2 weeks after their third vaccination. Symbols show individual values, horizontal bars show medians, horizontal dotted lines show lower (0·4 U/mL) and upper (2500 U/mL) detection limits. Red triangles show anti-S1 titres for patients on prednisone. Statistical analysis was performed using the Mann-Whitney U test for non-parametric data. S1=spike protein 1.

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